Goat Secondary Antibodies
Cayman Chemical Chondroitin Sulfate (sodium salt), CAS: 9082-07-9, 10 g
A glycosaminoglycan; contains a GAG-protein linker region and repeating disaccharide subunits composed of GlcA and GalNAc; chains of various lengths covalently attach to proteins to form CSPGs
Cayman Chemical 2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate (sodium salt), Purity: ≥95% (mixture of isomers), 3.2 mg
Fluorescent GTP derivatives; inhibits mammalian AC1 (Ki = 10 nM in the presence of manganese), B. anthracis AC toxin edema factor (Kis = 4.1 and 13 µM in the presence of manganese and magnesium, respectively), and B. pertussis AC toxin CyaA (Ki = 29 µM in the presence of manganese)
Cayman Chemical Anthraflavic Acid, Purity: ≥95%, CAS: 84-60-6, 10 g
An anthraquinone with diverse biological activities; inhibits α-amylase in a cell-free assay (IC50 = 198.3 nM) and cytochrome P450 activity induced by a mixture of PCBs in rat hepatic microsomes; binds to ERα and ERβ (Kis = 0.31 and 0.69 µM, respectively); cytotoxic against a panel of six cancer cell lines (IC50s = 156-241 µg/ml); inhibits Glu-P-1-induced mutagenicity in the Ames test using S. typhimurium at 50 µM; topical application reduces the number of tumors per mouse and the number of mice with tumors in a model of two-stage carcinogenesis initiated by DMBA and promoted by TPA; has been used as an anolyte in redox flow batteries
Cayman Chemical Pyridoxamine (hydrochloride), Purity: ≥98%, CAS: 524-36-7, 25 g
A 4-methylamine form of vitamin B6; scavenges isoketals in cell-free assays and inhibits the formation of lysyl-levuglandin-lactam adducts in dazoxiben-stimulated isolated human platelets at 0.1 and 1 mM; inhibits development of acellular capillaries and accumulation of CML in retina in a rat model of STZ-induced diabetes at 1 g/L in the drinking water; reverses STZ-induced deficits in the novel object recognition task in a rat model of diabetes at 0.4 and 1 g/L in the drinking water
Cayman Chemical Cholesterol (plant), Purity: ≥95%, CAS: 57-88-5, 250 mg
A minor plant sterol; a precursor in the synthesis of various bioactive plant metabolites
Cayman Chemical Pramoxine (hydrochloride), Purity: ≥98%, CAS: 637-58-1, 25 g
A local anesthetic; reduces electrically induced peak CAP amplitudes in isolated frog sciatic nerve (IC50 = 0.21 mM); topical administration inhibits winking in a rabbit corneal test, indicating anesthetic activity, at 0.35 and 0.6%; inhibits the pinprick-induced CTMR in the skin of rats (ED50 = 42.1 μmol, s.c.)
Cayman Chemical Cephalosporin C (zinc), Purity: ≥95%, CAS: 59143-60-1, 250 mg
A cephalosporin antibiotic; active against a variety of bacteria, including S. pyogenes, C. diphtheriae, E. coli, and H. influenzae (MICs = 31, 15.6, 125, and 31 µg/ml, respectively), as well as clinical isolates of N. gonorrhoeae (MICs = 1.9-15.6 µg/ml)
Cayman Chemical Metacetamol, Purity: ≥98%, CAS: 621-42-1, 100 g
A derivative of acetaminophen; not cytotoxic to isolated mouse hepatocytes (LC50 = >10 mM); induces necrosis and depletion of GSH in isolated human hepatocytes at 10 mM; does not induce hepatic necrosis in mice at 900 mg/kg
Cayman Chemical Azatadine (maleate), Purity: ≥98%, CAS: 3978-86-7, 500 mg
An antihistamine with anticholinergic and antiserotonergic activities; histamine H1 receptor antagonist (Ki = 3.9 nM); inhibits histamine- and acetylcholine-induced contractions in isolated guinea pig ilium and 5-HT-induced contractions in isolated rat uterus (EC50s = 6.5, 10, and 14 nM, respectively); delays the onset of dyspnea induced by aerosolized histamine, 5-HT, or acetylcholine in guinea pigs; prevents histamine-induced lethality in guinea pigs and paw edema in mice (ED50s = 9 and 68 μg/kg, respectively); increases survival in guinea pig and mouse models of anaphylactic shock (PD50s = 0.024 and 0.019 mg/kg, respectively)
Cayman Chemical Oxythiamine (chloride hydrochloride), Purity: ≥95%, CAS: 614-05-1, 1 g
A thiamine antimetabolite; converted by thiamine pyrophosphokinase to oxythiamine pyrophosphate; decreases transketolase activity in and is cytotoxic to MDA-MB-231 breast cancer cells at 5 mM; inhibits the nonoxidative synthesis of ribose and decreases RNA and DNA synthesis in MIA PaCa-2 pancreatic cancer cells at 0.5 µM; induces cell cycle arrest at the G0/G1 phase and apoptosis in an Ehrlich murine spontaneous adenocarcinoma model; reduces tumor growth in an SMMC mouse xenograft model in combination with sorafenib; has been used to induce thiamine deficiency in mice
Cayman Chemical Ilicicolin F, Purity: ≥70%, CAS: 22738-98-3, 1 mg
A fungal metabolite; inhibits T. vivax alternative oxidase and E. coli cytochrome bo (IC50s = 0.43 and 0.37 µM, respectively) but not E. coli cytochrome bd (IC50 = 85 µM); active against A. fumigatus and C. albicans (MICs = 1.66-3.33 and 6.66-13.33 µg/ml, respectively); cytotoxic to HeLa cells (EC50 = 0.003 µg/ml)
Cayman Chemical 1-Kestose, Purity: ≥95%, CAS: 470-69-9, 250 mg
A fructooligosaccharide with prebiotic and antidiabetic activities; increases levels of the beneficial bacterium B. longum in diluted adult human fecal samples in culture broth at 0.5% w/v; dietary supplementation increases the proportion of cecal Anaerostipes and Bifidobacteriumcontent, improves glucose tolerance, and prevents the development of type 2 diabetes in OLETF rats
Cayman Chemical (S)-3-Thienylglycine, Purity: ≥95%, CAS: 1194-87-2, 100 mg
A thienyl-containing amino acid; has been used as an affinity ligand to adsorb IgM and IgG antibodies from isolated human plasma
Cayman Chemical m-Methoxybenzamide, Purity: ≥98%, CAS: 5813-86-5, 25 g
A PARP inhibitor (Ki = <2 µM); inhibits human placental ADP ribosyl transferase activity by 93% at 100 µM; increases the pain threshold in the paw pinch test in rats at 100, 200, and 300 mg/kg
Cayman Chemical Ursodeoxycholic Acid, Purity: ≥95%, CAS: 128-13-2, 5 g
A secondary bile acid; formed via epimerization of CDCA; a metabolite of LCA in human liver microsomes; inhibits taurocholic acid uptake in HeLa cells expressing recombinant human NTCP (IC50 = 3.6 μM); inhibits apoptosis induced by DCA or ethanol in primary rat hepatocytes at 50 μM; dietary administration blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats